Protein oxidation and aging

Protein Oxidation and Aging

Aging and oxidation of reactive protein sulfhydryls.

Protein sulfhydryls are potential sites of reversible oxidative modification by S-glutathiolation, and S-nitrosylation, but they are also susceptible to irreversible damage by oxidative conditions. In the absence of adequate antioxidant protection, these reactive sites may become useless because of this irreversible damage. It has recently become possible to directly access the nature and amoun...

Rubber Oxidation and Tire Aging - a Review

While a new tire may have excellent resistance to crack initiation and propagation between the steel belts, an aged tire of the exact same construction can exhibit dramatically reduced crack growth resistance, which in some cases may contribute to tire failure. This article will review the research that has gone into quantifying the rate of oxidation the steel belt rubber oxidizes in different ...

Excess brain protein oxidation and enzyme dysfunction in normal aging and in Alzheimer disease.

The relationship between Alzheimer disease (AD) and aging is not currently known. In this study, postmortem frontal- and occipital-pole brain samples were obtained from 16 subjects with AD, 8 age-matched controls, and 5 young controls. These samples were analyzed both for protein oxidation products (carbonyl) and the activities of two enzymes vulnerable to mixed-function oxidation, glutamine sy...

Redox proteomics in aging rat brain: involvement of mitochondrial reduced glutathione status and mitochondrial protein oxidation in the aging process.

Increasing evidence supports the notion that increased oxidative stress is a fundamental cause in the aging process and in neurodegenerative diseases. As a result, a decline in cognitive function is generally associated with brain aging. Reactive oxygen species (ROS) are highly reactive intermediates, which can modify proteins, nucleic acids, and polyunsaturated fatty acids, leading to neuronal...